| Accession | TIGR01432 |
| Name | QOXA |
| Function | cytochrome aa3 quinol oxidase, subunit II |
| Gene Symbol | qoxA |
| Trusted Cutoff | 240.95 |
| Domain Trusted Cutoff | 240.95 |
| Noise Cutoff | 204.55 |
| Domain Noise Cutoff | 204.55 |
| Isology Type | equivalog |
| EC Number | 1.10.3.- |
| HMM Length | 227 |
| Mainrole Category | Energy metabolism |
| Subrole Category | Electron transport |
| Gene Ontology Term | GO:0009055: electron carrier activity molecular_function |
| | GO:0015002: heme-copper terminal oxidase activity molecular_function |
| | GO:0015078: hydrogen ion transmembrane transporter activity molecular_function |
| | GO:0015990: electron transport coupled proton transport biological_process |
| | GO:0016021: integral to membrane cellular_component |
| | GO:0016682: oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor molecular_function |
| | GO:0055114: oxidation-reduction process biological_process |
| Author | Selengut J |
| Entry Date | Feb 4 2002 10:20AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This enzyme catalyzes the oxidation of quinol with the concomitant reduction of molecular oxygen to water. This acts as the terminal electron acceptor in the respiratory chain. This subunit contains two transmembrane helices and a large external domain responsible for the binding and oxidation of quinol. QuoX is (presently) only found in gram positive bacteria of the Bacillus/Staphylococcus group. Like CyoA, the ubiquinol oxidase found in proteobacteria, the residues responsible for the ligation of Cu(a) and cytochrome c (found in the related cyt. c oxidases) are absent. Unlike CyoA, QoxA is in complex with a subunit I which contains cytochromes a similar to the cyt. c oxidases (as opposed to cytochromes b). |
| References | RN [1]
RM 1316894
RT Molecular cloning, sequencing, and physiological characterization of the qox operon from Bacillus subtilis encoding the aa3-600 quinol oxidase
RA Santana M, Kunst F, Hullo MF, Rapoport G, Danchin A, Glaser P
RL J Biol Chem 1992 May 25;267(15):10225-31
DR EXPERIMENTAL; SP|P34957; Bacillus subtilis caa3-600
DR PROSITE; PR02790; COX2_TM; partial hit; score = 2.55
DR OUTGROUP; EGAD 20044; Escherichia coli CyoA |
| Genome Property | GenProp0620: cytochrome (quinone) oxidase, aa3 type, QoxABCD (HMM) |
