HMM Summary Page: TIGR01428

Functionhaloacid dehalogenase, type II
Gene SymboldehII
Trusted Cutoff125.40
Domain Trusted Cutoff125.40
Noise Cutoff72.30
Domain Noise Cutoff72.30
Isology Typeequivalog
EC Number3.8.1.2
HMM Length197
Gene Ontology TermGO:0006805: xenobiotic metabolic process biological_process
GO:0018784: (S)-2-haloacid dehalogenase activity molecular_function
AuthorSelengut J
Entry DateFeb 1 2002 11:59AM
Last ModifiedFeb 14 2011 3:27PM
CommentCatalyzes the hydrolytic dehalogenation of small L-2-haloalkanoic acids to yield the corresponding D-2-hydroxyalkanoic acids. Belongs to the Haloacid Dehalogenase (HAD) superfamily of aspartate-nucleophile hydrolases (PF00702), class (subfamily) I. Note that the Type I HAD enzymes have not yet been fully characterized, but clearly utilize a substantially different catalytic mechanism and are thus unlikely to be related.
ReferencesRN [1] RM 1744048 RT Characterization of the haloacid dehalogenase from Xanthobacter autotrophicus GJ10 and sequencing of the dhlB gene RA van der Ploeg J, van Hall G, Janssen DB RL J Bacteriol 1991 Dec;173(24):7925-33 RN [2] RM 10498712 RT Cloning and characterization of a cryptic haloacid dehalogenase from Burkholderia cepacia MBA4 RA Tsang JS, Sam L RL J Bacteriol 1999 Oct;181(19):6003-9 RN [3] RM 10198020 RT nvestigation of two evolutionarily unrelated halocarboxylic acid dehalogenase gene families RA Hill KE, Marchesi JR, Weightman AJ RL J Bacteriol 1999 Apr;181(8):2535-47 RN [4] RM 11404103 RT Microbial dehalogenation RA Janssen DB, Oppentocht JE, Poelarends GJ RL Curr Opin Biotechnol 2001 Jun;12(3):254-8 DR PFAM; PF00702; hydrolase DR EXPERIMENTAL; GP|4127501; cryptic, not expressed by all individuals in a culture; Burkholderia cepacia MBA4 DR EXPERIMENTAL; GP|4468659; Pseudomonas putida PP3