HMM Summary Page: TIGR01423

Functiontrypanothione-disulfide reductase
Gene SymbolTpr
Trusted Cutoff738.10
Domain Trusted Cutoff738.10
Noise Cutoff459.70
Domain Noise Cutoff459.70
Isology Typeequivalog
EC Number1.8.1.12
HMM Length486
Gene Ontology TermGO:0015042: trypanothione-disulfide reductase activity molecular_function
GO:0030503: regulation of cell redox homeostasis biological_process
GO:0055114: oxidation-reduction process biological_process
AuthorHaft DH
Entry DateJan 28 2002 11:05AM
Last ModifiedFeb 14 2011 3:27PM
CommentTrypanothione, a glutathione-modified derivative of spermidine, is (in its reduced form) an important antioxidant found in trypanosomatids (Crithidia, Leishmania, Trypanosoma). This model describes trypanothione reductase, a possible antitrypanosomal drug target closely related to some forms of glutathione reductase.