HMM Summary Page: TIGR01421

Functionglutathione-disulfide reductase
Gene Symbolgor
Trusted Cutoff556.15
Domain Trusted Cutoff556.15
Noise Cutoff457.25
Domain Noise Cutoff457.25
Isology Typeequivalog
EC Number1.8.1.7
HMM Length450
Mainrole CategoryEnergy metabolism
Subrole CategoryElectron transport
Gene Ontology TermGO:0004362: glutathione-disulfide reductase activity molecular_function
GO:0030503: regulation of cell redox homeostasis biological_process
GO:0055114: oxidation-reduction process biological_process
AuthorHaft DH
Entry DateJan 28 2002 10:51AM
Last ModifiedFeb 14 2011 3:27PM
CommentThe tripeptide glutathione is an important reductant, e.g., for maintaining the cellular thiol/disulfide status and for protecting against reactive oxygen species such as hydrogen peroxide. Glutathione-disulfide reductase regenerates reduced glutathione from oxidized glutathione (glutathione disulfide) + NADPH. This HMM represents one of two closely related subfamilies of glutathione-disulfide reductase. Both are closely related to trypanothione reductase, and separate models are built so each of the three can describe proteins with conserved function. This model describes glutathione-disulfide reductases of animals, yeast, and a number of animal-resident bacteria.