HMM Summary Page: TIGR01420

Functiontwitching motility protein
Trusted Cutoff319.10
Domain Trusted Cutoff319.10
Noise Cutoff220.05
Domain Noise Cutoff220.05
Isology Typesubfamily
HMM Length343
Mainrole CategoryCell envelope
Subrole CategorySurface structures
Gene Ontology TermGO:0005524: ATP binding molecular_function
GO:0043107: type IV pilus-dependent motility biological_process
AuthorHaft DH
Entry DateJan 22 2002 1:35PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model represents the PilT subfamily of proteins related to GspE, a protein involved in type II secretion (also called the General Secretion Pathway). PilT is an apparent cytosolic ATPase associated with type IV pilus systems. It is not required for pilin biogenesis, but is required for twitching motility and social gliding behaviors, shown in some species, powered by pilus retraction. Members of this family may be found in some species that type IV pili but have related structures for DNA uptake and natural transformation.
ReferencesRM 10993081 RT Pilus retraction powers bacterial twitching motility. RA Merz AJ, So M, Sheetz MP. RL Nature 2000 Sep 7;407(6800):98-102