HMM Summary Page: TIGR01418

Functionphosphoenolpyruvate synthase
Gene SymbolppsA
Trusted Cutoff739.75
Domain Trusted Cutoff739.75
Noise Cutoff338.15
Domain Noise Cutoff338.15
Isology Typeequivalog
EC Number2.7.9.2
HMM Length784
Mainrole CategoryEnergy metabolism
Subrole CategoryGlycolysis/gluconeogenesis
Gene Ontology TermGO:0006094: gluconeogenesis biological_process
GO:0008986: pyruvate, water dikinase activity molecular_function
GO:0009401: phosphoenolpyruvate-dependent sugar phosphotransferase system biological_process
AuthorHaft DH
Entry DateJan 16 2002 11:13AM
Last ModifiedFeb 14 2011 3:27PM
CommentAlso called pyruvate,water dikinase and PEP synthase. The member from Methanococcus jannaschii contains a large intein. This enzyme generates phosphoenolpyruvate (PEP) from pyruvate, hydrolyzing ATP to AMP and releasing inorganic phosphate in the process. The enzyme shows extensive homology to other enzymes that use PEP as substrate or product. This enzyme may provide PEP for gluconeogenesis, for PTS-type carbohydrate transport systems, or for other processes.
ReferencesDR EXPERIMENTAL; EGAD|36981; Pyrococcus furiosus DR EXPERIMENTAL; SP|P23538; Escherichia coli