| Accession | TIGR01418 |
| Name | PEP_synth |
| Function | phosphoenolpyruvate synthase |
| Gene Symbol | ppsA |
| Trusted Cutoff | 739.75 |
| Domain Trusted Cutoff | 739.75 |
| Noise Cutoff | 338.15 |
| Domain Noise Cutoff | 338.15 |
| Isology Type | equivalog |
| EC Number | 2.7.9.2 |
| HMM Length | 784 |
| Mainrole Category | Energy metabolism |
| Subrole Category | Glycolysis/gluconeogenesis |
| Gene Ontology Term | GO:0006094: gluconeogenesis biological_process |
| | GO:0008986: pyruvate, water dikinase activity molecular_function |
| | GO:0009401: phosphoenolpyruvate-dependent sugar phosphotransferase system biological_process |
| Author | Haft DH |
| Entry Date | Jan 16 2002 11:13AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Also called pyruvate,water dikinase and PEP synthase. The member from Methanococcus jannaschii contains a large intein. This enzyme generates phosphoenolpyruvate (PEP) from pyruvate, hydrolyzing ATP to AMP and releasing inorganic phosphate in the process. The enzyme shows extensive homology to other enzymes that use PEP as substrate or product. This enzyme may provide PEP for gluconeogenesis, for PTS-type carbohydrate transport systems, or for other processes. |
| References | DR EXPERIMENTAL; EGAD|36981; Pyrococcus furiosus
DR EXPERIMENTAL; SP|P23538; Escherichia coli |
