HMM Summary Page: TIGR01393

Functionelongation factor 4
Gene SymbollepA
Trusted Cutoff533.90
Domain Trusted Cutoff533.90
Noise Cutoff260.40
Domain Noise Cutoff260.40
Isology Typeequivalog
EC Number3.6.5.-
HMM Length595
Mainrole CategoryUnknown function
Subrole CategoryGeneral
Gene Ontology TermGO:0005525: GTP binding molecular_function
AuthorHaft DH
Entry DateDec 11 2001 1:36PM
Last ModifiedDec 21 2011 12:47PM
CommentLepA (GUF1 in Saccaromyces), now called elongation factor 4, is a GTP-binding membrane protein related to EF-G and EF-Tu. Two types of phylogenetic tree, rooted by other GTP-binding proteins, suggest that eukaryotic homologs (including GUF1 of yeast) originated within the bacterial LepA family. The function is unknown.
ReferencesDR HAMAP; MF_00071; 493 of 500 RN [1] RM PMID:21930951 RT The conserved protein EF4 (LepA) modulates the elongation cycle of protein synthesis. RA Liu H, Chen C, Zhang H, Kaur J, Goldman YE, Cooperman BS RL Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16223-8.
Genome PropertyGenProp0799: bacterial core gene set, exactly 1 per genome (HMM)