| Accession | TIGR01393 |
| Name | lepA |
| Function | elongation factor 4 |
| Gene Symbol | lepA |
| Trusted Cutoff | 533.90 |
| Domain Trusted Cutoff | 533.90 |
| Noise Cutoff | 260.40 |
| Domain Noise Cutoff | 260.40 |
| Isology Type | equivalog |
| EC Number | 3.6.5.- |
| HMM Length | 595 |
| Mainrole Category | Unknown function |
| Subrole Category | General |
| Gene Ontology Term | GO:0005525: GTP binding molecular_function |
| Author | Haft DH |
| Entry Date | Dec 11 2001 1:36PM |
| Last Modified | Dec 21 2011 12:47PM |
| Comment | LepA (GUF1 in Saccaromyces), now called elongation factor 4, is a GTP-binding membrane protein related to EF-G and EF-Tu. Two types of phylogenetic tree, rooted by other GTP-binding proteins, suggest that eukaryotic homologs (including GUF1 of yeast) originated within the bacterial LepA family. The function is unknown. |
| References | DR HAMAP; MF_00071; 493 of 500
RN [1]
RM PMID:21930951
RT The conserved protein EF4 (LepA) modulates the elongation cycle of protein synthesis.
RA Liu H, Chen C, Zhang H, Kaur J, Goldman YE, Cooperman BS
RL Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16223-8. |
| Genome Property | GenProp0799: bacterial core gene set, exactly 1 per genome (HMM) |
