HMM Summary Page: TIGR01390

Function2',3'-cyclic-nucleotide 2'-phosphodiesterase
Gene SymbolcpdB
Trusted Cutoff883.00
Domain Trusted Cutoff883.00
Noise Cutoff412.80
Domain Noise Cutoff412.80
Isology Typeequivalog
EC Number3.1.4.16
HMM Length626
Mainrole CategoryPurines, pyrimidines, nucleosides, and nucleotides
Subrole CategoryOther
Gene Ontology TermGO:0006139: nucleobase-containing compound metabolic process biological_process
GO:0008663: 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity molecular_function
GO:0009897: external side of plasma membrane cellular_component
GO:0030288: outer membrane-bounded periplasmic space cellular_component
AuthorBeanan M
Entry DateDec 7 2001 12:17PM
Last ModifiedFeb 14 2011 3:27PM
Comment2',3'-cyclic-nucleotide 2'-phosphodiesterase is a bifunctional enzyme localized to the periplasm of Gram-negative bacteria. 2',3'-cyclic-nucleotide 2'-phosphodiesters are intermediates formed during the hydrolysis of RNA by the ribonuclease I, which is also found to the periplasm, and other enzymes of the RNAse T2 family. Bacteria are unable to transport 2',3'-cyclic-nucleotides into the cytoplasm. 2',3'-cyclic-nucleotide 2'-phosphodiesterase contains 2 active sites which catalyze the reactions that convert the 2',3'-cyclic-nucleotide into a 3'-nucleotide, which is then converted into nucleic acid and phosphate. Both final products can be transported into the cytoplasm. Thus, it has been suggested that 2',3'-cyclic-nucleotide 2'-phosphodiesterase has a 'scavenging' function. Experimental evidence indicates that 2',3'-cyclic-nucleotide 2'-phosphodiesterase enables Yersinia enterocolitica O:8 to grow on 2'3'-cAMP as a sole source of carbon and energy (PMID:11160814).