HMM Summary Page: TIGR01384

Functiontranscription factor S
Trusted Cutoff64.75
Domain Trusted Cutoff64.75
Noise Cutoff56.50
Domain Noise Cutoff56.50
Isology Typeequivalog
HMM Length101
Mainrole CategoryTranscription
Subrole CategoryTranscription factors
Gene Ontology TermGO:0003700: sequence-specific DNA binding transcription factor activity molecular_function
GO:0006350: transcription biological_process
AuthorHaft DH
Entry DateNov 27 2001 10:12AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model describes archaeal transcription factor S, a protein related in size and sequence to certain eukaryotic RNA polymerase small subunits, and in sequence and function to the much larger eukaryotic transcription factor IIS (TFIIS). Although originally suggested to be a subunit of the archaeal RNA polymerase, it elutes separately from active polymerase in gel filtration experiments and acts, like TFIIs, as an induction factor for RNA cleavage by RNA polymerase. There has been an apparent duplication event in the Halobacteriaceae lineage (Haloarcula, Haloferax, Haloquadratum, Halobacterium and Natromonas). There appears to be a separate duplication in Methanosphaera stadtmanae.
ReferencesRM 20239876 RT Transcription factor S, a cleavage induction factor of the archaeal RNA polymerase. RA Hausner W, Lange U, Musfeldt M. RL J Biol Chem 2000 Apr 28;275(17):12393-9 DR EXPERIMENTAL; GP|6723838; Methanococcus thermolithotrophicus
Genome PropertyGenProp0832: archaeal core gene set, 1 or more per genome (HMM)