HMM Summary Page: TIGR01382

Functionintracellular protease, PfpI family
Trusted Cutoff139.05
Domain Trusted Cutoff139.05
Noise Cutoff112.55
Domain Noise Cutoff112.55
Isology Typesubfamily
HMM Length169
Mainrole CategoryProtein fate
Subrole CategoryDegradation of proteins, peptides, and glycopeptides
Gene Ontology TermGO:0006508: proteolysis biological_process
GO:0008234: cysteine-type peptidase activity molecular_function
AuthorHaft DH
Entry DateNov 19 2001 11:02AM
Last ModifiedFeb 14 2011 3:27PM
CommentThe member of this family from Pyrococcus horikoshii has been solved to 2 Angstrom resolution. It is an ATP-independent intracellular protease that crystallizes as a hexameric ring. Cys-101 is proposed as the active site residue in a catalytic triad with the adjacent His-102 and a Glu residue from an adjacent monomer. A member of this family from Bacillus subtilis, GSP18, has been shown to be expressed in response to several forms of stress. A role in the degradation of small peptides has been suggested. A closely related family consists of the thiamine biosynthesis protein ThiJ and its homologs.
ReferencesRM 11114201 RT Crystal structure of an intracellular protease from Pyrococcus horikoshii at 2-A resolution. RA Du X, Choi IG, Kim R, Wang W, Jancarik J, Yokota H, Kim SH. RL Proc Natl Acad Sci U S A 2000 Dec 19;97(26):14079-84