HMM Summary Page: TIGR01381

FunctionE1-like protein-activating enzyme Gsa7p/Apg7p
Trusted Cutoff571.35
Domain Trusted Cutoff571.35
Noise Cutoff304.85
Domain Noise Cutoff304.85
Isology Typeequivalog
HMM Length663
Gene Ontology TermGO:0006497: protein lipidation biological_process
GO:0006944: cellular membrane fusion biological_process
AuthorHaft DH
Entry DateNov 16 2001 4:28PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM represents a family of eukaryotic proteins found in animals, plants, and yeasts, including Apg7p (YHR171W) from Saccharomyces cerevisiae and GSA7 from Pichia pastoris. Members are about 650 to 700 residues in length and include a central domain of about 150 residues shared with the ThiF/MoeB/HesA family of proteins. A low level of similarity to ubiquitin-activating enzyme E1 is described in a paper on peroxisome autophagy mediated by GSA7, and is the basis of the name ubiquitin activating enzyme E1-like protein. Members of the family appear to be involved in protein lipidation events analogous to ubiquitination and required for membrane fusion events during autophagy.