HMM Summary Page: TIGR01380

Functionglutathione synthase
Gene SymbolgshB
Trusted Cutoff299.05
Domain Trusted Cutoff299.05
Noise Cutoff112.05
Domain Noise Cutoff112.05
Isology Typeequivalog
EC Number6.3.2.3
HMM Length312
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryGlutathione and analogs
Gene Ontology TermGO:0004363: glutathione synthase activity molecular_function
GO:0006750: glutathione biosynthetic process biological_process
AuthorBeanan M
Entry DateNov 16 2001 3:48PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model was built using glutathione synthetases found in Gram-negative bacteria. This gene does not appear to be present in genomes of Gram-positive bacteria. Glutathione synthetase has an ATP-binding domain in the COOH terminus and catalyzes the second step in the glutathione biosynthesis pathway: ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione. Glutathione is a tripeptide that functions as a reductant in many cellular reactions.
References DR HAMAP; MF_00162; 51 of 51
Genome PropertyGenProp0030: glutathione biosynthesis (HMM)