| Accession | TIGR01379 |
| Name | thiL |
| Function | thiamine-phosphate kinase |
| Gene Symbol | thiL |
| Trusted Cutoff | 184.15 |
| Domain Trusted Cutoff | 184.15 |
| Noise Cutoff | 113.70 |
| Domain Noise Cutoff | 113.70 |
| Isology Type | equivalog |
| EC Number | 2.7.4.16 |
| HMM Length | 320 |
| Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
| Subrole Category | Thiamine |
| Gene Ontology Term | GO:0009030: thiamine-phosphate kinase activity molecular_function |
| | GO:0009228: thiamine biosynthetic process biological_process |
| Author | Haft DH |
| Entry Date | Nov 15 2001 3:23PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This HMM describes thiamine-monophosphate kinase, an enzyme that converts thiamine monophosphate into thiamine pyrophosphate (TPP, coenzyme B1), an enzyme cofactor. Thiamine monophosphate may be derived from de novo synthesis or from unphosphorylated thiamine, known as vitamin B1.
Proteins scoring between the trusted and noise cutoff for this model include short forms from the Thermoplasmas (which lack the N-terminal region) and a highly derived form from Campylobacter jejuni. Eukaryotes lack this enzyme, and add pyrophosphate from ATP to unphosphorylated thiamine in a single step. |
| References | DR EXPERIMENTAL; SP:P77785; Escherichia coli
DR OUTGROUP; OMNI|NTL01MT00202; hydrogenase expression/formation protein HypE |
| Genome Property | GenProp0254: thiamine: TPP from HMP-PP and HET-P (HMM) |
