| Accession | TIGR01378 |
| Name | thi_PPkinase |
| Function | thiamine pyrophosphokinase |
| Trusted Cutoff | 76.40 |
| Domain Trusted Cutoff | 76.40 |
| Noise Cutoff | 67.85 |
| Domain Noise Cutoff | 67.85 |
| Isology Type | equivalog |
| EC Number | 2.7.6.2 |
| HMM Length | 206 |
| Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
| Subrole Category | Thiamine |
| Gene Ontology Term | GO:0004788: thiamine diphosphokinase activity molecular_function |
| | GO:0006772: thiamine metabolic process biological_process |
| Author | Haft DH |
| Entry Date | Nov 15 2001 2:52PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This model has been revised. Originally, it described strictly eukaryotic thiamine pyrophosphokinase. However, it is now expanded to include also homologous enzymes, apparently functionally equivalent, from species that rely on thiamine pyrophosphokinase rather than thiamine-monophosphate kinase (TIGR01379) to produce the active TPP cofactor. This includes the thiamine pyrophosphokinase from Bacillus subtilis, previously designated YloS. |
| References | RM 15150256
RT Identification of the two missing bacterial genes involved in thiamine salvage: thiamine pyrophosphokinase and thiamine kinase.
RA Melnick J, Lis E, Park JH, Kinsland C, Mori H, Baba T, Perkins J, Schyns G, Vassieva O, Osterman A, Begley TP.
RL J Bacteriol. 2004 Jun;186(11):3660-2. |
| Genome Property | GenProp0254: thiamine: TPP from HMP-PP and HET-P (HMM) |
