HMM Summary Page: TIGR01378

Functionthiamine pyrophosphokinase
Trusted Cutoff76.40
Domain Trusted Cutoff76.40
Noise Cutoff67.85
Domain Noise Cutoff67.85
Isology Typeequivalog
EC Number2.7.6.2
HMM Length206
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryThiamine
Gene Ontology TermGO:0004788: thiamine diphosphokinase activity molecular_function
GO:0006772: thiamine metabolic process biological_process
AuthorHaft DH
Entry DateNov 15 2001 2:52PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model has been revised. Originally, it described strictly eukaryotic thiamine pyrophosphokinase. However, it is now expanded to include also homologous enzymes, apparently functionally equivalent, from species that rely on thiamine pyrophosphokinase rather than thiamine-monophosphate kinase (TIGR01379) to produce the active TPP cofactor. This includes the thiamine pyrophosphokinase from Bacillus subtilis, previously designated YloS.
ReferencesRM 15150256 RT Identification of the two missing bacterial genes involved in thiamine salvage: thiamine pyrophosphokinase and thiamine kinase. RA Melnick J, Lis E, Park JH, Kinsland C, Mori H, Baba T, Perkins J, Schyns G, Vassieva O, Osterman A, Begley TP. RL J Bacteriol. 2004 Jun;186(11):3660-2.
Genome PropertyGenProp0254: thiamine: TPP from HMP-PP and HET-P (HMM)