HMM Summary Page: TIGR01372

Functionsarcosine oxidase, alpha subunit family
Trusted Cutoff1164.00
Domain Trusted Cutoff1164.00
Noise Cutoff906.05
Domain Noise Cutoff906.05
Isology Typesubfamily
HMM Length996
Mainrole CategoryEnergy metabolism
Subrole CategoryAmino acids and amines
AuthorDodson RJ
Entry DateNov 2 2001 3:55PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes the alpha subunit of a family of known and putative heterotetrameric sarcosine oxidases. Five operons of such oxidases are found in Mesorhizobium loti and three in Agrobacterium tumefaciens, a high enough copy number to suggest that not all members are share the same function. The model is designated as subfamily rather than equivalog for this reason.Sarcosine oxidase catalyzes the oxidative demethylation of sarcosine to glycine. The reaction converts tetrahydrofolate to 5,10-methylene-tetrahydrofolate. The enzyme is known in monomeric and heterotetrameric (alpha,beta,gamma,delta) forms