HMM Summary Page: TIGR01363

Functionstreptococcal histidine triad protein
Trusted Cutoff33.00
Domain Trusted Cutoff33.00
Noise Cutoff25.00
Domain Noise Cutoff25.00
Isology Typesubfamily_domain
HMM Length348
Mainrole CategoryCellular processes
Subrole CategoryPathogenesis
AuthorHaft DH
Entry DateOct 23 2001 8:27AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM represents the N-terminal half of a family of Streptococcal proteins that contain a signal peptide and then up to five repeats of a region that includes a His-X-X-His-X-His (histidine triad) motif. Three repeats are found in the seed alignment. Additional copies in more poorly conserved regions can be detected because this is a fragment-mode HMM. Members of this family from Streptococcus pneumoniae are suggested to cleave human C3, and the member PhpA has been shown in vaccine studies to be a protective antigen in mice.
ReferencesRM 11349048 RT Recombinant PhpA protein, a unique histidine motif-containing protein from Streptococcus pneumoniae, protects mice against intranasal pneumococcal challenge. RA Zhang Y, Masi AW, Barniak V, Mountzouros K, Hostetter MK, Green BA RL Infect Immun 2001 Jun;69(6):3827-36