| Accession | TIGR01362 |
| Name | KDO8P_synth |
| Function | 3-deoxy-8-phosphooctulonate synthase |
| Gene Symbol | kdsA |
| Trusted Cutoff | 314.00 |
| Domain Trusted Cutoff | 314.00 |
| Noise Cutoff | 139.00 |
| Domain Noise Cutoff | 139.00 |
| Isology Type | equivalog |
| EC Number | 2.5.1.55 |
| HMM Length | 258 |
| Mainrole Category | Cell envelope |
| Subrole Category | Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides |
| Gene Ontology Term | GO:0008676: 3-deoxy-8-phosphooctulonate synthase activity molecular_function |
| | GO:0019294: keto-3-deoxy-D-manno-octulosonic acid biosynthetic process biological_process |
| Author | Haft DH |
| Entry Date | Oct 19 2001 5:10PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This HMM describes 3-deoxy-8-phosphooctulonate synthase. Alternate names include 2-dehydro-3-deoxyphosphooctonate aldolase, 3-deoxy-d-manno-octulosonic acid 8-phosphate and KDO-8 phosphate synthetase. It catalyzes the aldol condensation of phosphoenolpyruvate with D-arabinose 5-phosphate:
phosphoenolpyruvate + D-arabinose 5-phosphate + H2O = 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate
In Gram-negative bacteria, this is the first step in the biosynthesis of 3-deoxy-D-manno-octulosonate, part of the oligosaccharide core of lipopolysaccharide. |
| References | DR PF00793; DAHP_synth_1
DR InterPro; IPR001785; DAHP_synth_1
DR HAMAP; MF_00056; 216 of 218 |
| Genome Property | GenProp0204: KDO(2)-lipid A (Re LPS) biosynthesis and delivery (HMM) |
