HMM Summary Page: TIGR01362

Function3-deoxy-8-phosphooctulonate synthase
Gene SymbolkdsA
Trusted Cutoff314.00
Domain Trusted Cutoff314.00
Noise Cutoff139.00
Domain Noise Cutoff139.00
Isology Typeequivalog
EC Number2.5.1.55
HMM Length258
Mainrole CategoryCell envelope
Subrole CategoryBiosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Gene Ontology TermGO:0008676: 3-deoxy-8-phosphooctulonate synthase activity molecular_function
GO:0019294: keto-3-deoxy-D-manno-octulosonic acid biosynthetic process biological_process
AuthorHaft DH
Entry DateOct 19 2001 5:10PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes 3-deoxy-8-phosphooctulonate synthase. Alternate names include 2-dehydro-3-deoxyphosphooctonate aldolase, 3-deoxy-d-manno-octulosonic acid 8-phosphate and KDO-8 phosphate synthetase. It catalyzes the aldol condensation of phosphoenolpyruvate with D-arabinose 5-phosphate: phosphoenolpyruvate + D-arabinose 5-phosphate + H2O = 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate In Gram-negative bacteria, this is the first step in the biosynthesis of 3-deoxy-D-manno-octulosonate, part of the oligosaccharide core of lipopolysaccharide.
ReferencesDR PF00793; DAHP_synth_1 DR InterPro; IPR001785; DAHP_synth_1 DR HAMAP; MF_00056; 216 of 218
Genome PropertyGenProp0204: KDO(2)-lipid A (Re LPS) biosynthesis and delivery (HMM)