| Accession | TIGR01358 |
| Name | DAHP_synth_II |
| Function | 3-deoxy-7-phosphoheptulonate synthase |
| Trusted Cutoff | 614.70 |
| Domain Trusted Cutoff | 614.70 |
| Noise Cutoff | 464.35 |
| Domain Noise Cutoff | 464.35 |
| Isology Type | equivalog |
| EC Number | 2.5.1.54 |
| HMM Length | 443 |
| Mainrole Category | Amino acid biosynthesis |
| Subrole Category | Aromatic amino acid family |
| Gene Ontology Term | GO:0003849: 3-deoxy-7-phosphoheptulonate synthase activity molecular_function |
| | GO:0009423: chorismate biosynthetic process biological_process |
| Author | Haft DH |
| Entry Date | Oct 9 2001 3:36PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This HMM represents the class II family of 3-deoxy-7-phosphoheptulonate synthase, aka phospho-2-dehydro-3-deoxyheptonate aldolase, as found in plants and some bacteria. It shows some similarity to the class I family found in many bacteria. The enzyme catalyzes the first of 7 steps in the biosynthesis of chorismate, that last common precursor of all three aromatic amino acids.
Homologs scoring between trusted and noise cutoff include proteins involved in antibiotic biosynthesis; one example is active as this enzyme, while another acts on an amino analog. |
| References | DR COGS; COG3200
DR EXPERIMENTAL; SP|P80574; Streptomyces coelicolor
DR EXPERIMENTAL; SP|P29976; Arabidopsis thaliana; 1
DR EXPERIMENTAL; SP|Q00218; Arabidopsis thaliana; 2 |
| Genome Property | GenProp0001: chorismate biosynthesis via shikimate (HMM) |
