HMM Summary Page: TIGR01353

Functionputative dGTPase
Gene Symboldgt
Trusted Cutoff152.35
Domain Trusted Cutoff152.35
Noise Cutoff116.90
Domain Noise Cutoff116.90
Isology Typesubfamily
EC Number3.1.5.1
HMM Length389
Mainrole CategoryPurines, pyrimidines, nucleosides, and nucleotides
Subrole CategoryNucleotide and nucleoside interconversions
Gene Ontology TermGO:0008832: dGTPase activity molecular_function
GO:0015949: nucleobase-containing small molecule interconversion biological_process
AuthorHaft DH
Entry DateOct 4 2001 1:39PM
Last ModifiedFeb 14 2011 3:27PM
CommentdGTP triphosphohydrolase (dgt) releases inorganic triphosphate, an unusual activity reaction product, from GTP. Its activity has been called limited to the Enterobacteriaceae, although homologous sequences are detected elsewhere. This finding casts doubt on whether the activity is shared in other species. In several of these other species, the homologous gene is found in an apparent operon with dnaG, the DNA primase gene. The enzyme from E. coli was shown to bind coopertatively to single stranded DNA. The biological role of dgt is unknown.
ReferencesDR EXPERIMENTAL; SP|P15723; Escherichia coli DR EXPERIMENTAL; SP|Q59827; Shigella boydii RM 9422594 RT Characterization of the dnaG locus in Mycobacterium smegmatis reveals linkage of DNA replication and cell division. RA Klann AG, Belanger AE, Abanes-De Mello A, Lee JY, Hatfull GF. RL J Bacteriol 1998 Jan;180(1):65-72 DR HAMAP; MF_01213; 6 of 6