HMM Summary Page: TIGR01350

Functiondihydrolipoyl dehydrogenase
Gene SymbollpdA
Trusted Cutoff408.80
Domain Trusted Cutoff408.80
Noise Cutoff400.75
Domain Noise Cutoff400.75
Isology Typeequivalog
EC Number1.8.1.4
HMM Length461
Gene Ontology TermGO:0004148: dihydrolipoyl dehydrogenase activity molecular_function
GO:0005624: membrane fraction cellular_component
GO:0006096: glycolysis biological_process
GO:0045454: cell redox homeostasis biological_process
GO:0051068: dihydrolipoamide metabolic process biological_process
AuthorHaft DH
Entry DateSep 25 2001 10:59AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes dihydrolipoamide dehydrogenase, a flavoprotein that acts in a number of ways. It is the E3 component of dehydrogenase complexes for pyruvate, 2-oxoglutarate, 2-oxoisovalerate, and acetoin. It can also serve as the L protein of the glycine cleavage system. This family includes a few members known to have distinct functions (ferric leghemoglobin reductase and NADH:ferredoxin oxidoreductase) but that may be predicted by homology to act as dihydrolipoamide dehydrogenase as well. The motif GGXCXXXGCXP near the N-terminus contains a redox-active disulfide.
ReferencesDR EXPERIMENTAL; SP|Q04829; Halobacterium volcanii DR EXPERIMENTAL; SP|P00391; Escherichia coli DR EXPERIMENTAL; SP:P11959; Bacillus stearothermophilus DR EXPERIMENTAL; SP|P31023; Pisum sativum DR EXCEPTION; GP:546360; ferric leghemoglobin reductase; Glycine max DR EXCEPTION; GP:5823556; ferric leghemoglobin reductase; Vigna unguiculata
Genome PropertyGenProp0178: glycine cleavage system (HMM)
GenProp0630: 2-oxoglutarate dehydrogenase system (HMM)