HMM Summary Page: TIGR01349

Functionpyruvate dehydrogenase complex dihydrolipoamide acetyltransferase
Trusted Cutoff445.00
Domain Trusted Cutoff445.00
Noise Cutoff277.20
Domain Noise Cutoff277.20
Isology Typeequivalog
EC Number2.3.1.12
HMM Length437
Mainrole CategoryEnergy metabolism
Subrole CategoryPyruvate dehydrogenase
Gene Ontology TermGO:0004738: pyruvate dehydrogenase activity molecular_function
GO:0004742: dihydrolipoyllysine-residue acetyltransferase activity molecular_function
GO:0006086: acetyl-CoA biosynthetic process from pyruvate biological_process
GO:0045254: pyruvate dehydrogenase complex cellular_component
AuthorHaft DH
Entry DateSep 24 2001 11:45AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model represents one of several closely related clades of the dihydrolipoamide acetyltransferase subunit of the pyruvate dehydrogenase complex. It includes sequences from mitochondria and from alpha and beta branches of the proteobacteria, as well as from some other bacteria. Sequences from Gram-positive bacteria are not included. The non-enzymatic homolog protein X, which serves as an E3 component binding protein, falls within the clade phylogenetically but is rejected by its low score.