HMM Summary Page: TIGR01348

Functiondihydrolipoyllysine-residue acetyltransferase
Gene SymbolaceF
Trusted Cutoff552.10
Domain Trusted Cutoff552.10
Noise Cutoff407.30
Domain Noise Cutoff407.30
Isology Typeequivalog
EC Number2.3.1.12
HMM Length587
Mainrole CategoryEnergy metabolism
Subrole CategoryPyruvate dehydrogenase
Gene Ontology TermGO:0004742: dihydrolipoyllysine-residue acetyltransferase activity molecular_function
GO:0006086: acetyl-CoA biosynthetic process from pyruvate biological_process
GO:0045254: pyruvate dehydrogenase complex cellular_component
AuthorHaft DH
Entry DateSep 24 2001 11:02AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes a subset of pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase specifically close by both phylogenetic and per cent identity (UPGMA) trees. Members of this set include two or three copies of the lipoyl-binding domain. E. coli AceF is a member of this model, while mitochondrial and some other bacterial forms belong to a separate model.
ReferencesDR SWISSPROT; ODP2_ECOLI; annotated entry DR ECOCYC; EG10025; aceF DR PF00198; 2-oxoacid_dh; one copy DR PF00364; biotin_lipoyl; two or three copies.