HMM Summary Page: TIGR01347

Functiondihydrolipoyllysine-residue succinyltransferase, E2 component of oxoglutarate dehydrogenase (succinyl-transferring) complex
Gene SymbolsucB
Trusted Cutoff378.65
Domain Trusted Cutoff378.65
Noise Cutoff329.90
Domain Noise Cutoff329.90
Isology Typeequivalog
EC Number2.3.1.61
HMM Length404
Mainrole CategoryEnergy metabolism
Subrole CategoryTCA cycle
Gene Ontology TermGO:0004149: dihydrolipoyllysine-residue succinyltransferase activity molecular_function
GO:0006099: tricarboxylic acid cycle biological_process
GO:0006554: lysine catabolic process biological_process
GO:0045252: oxoglutarate dehydrogenase complex cellular_component
AuthorHaft DH
Entry DateSep 21 2001 10:55AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes the TCA cycle 2-oxoglutarate system E2 component, dihydrolipoamide succinyltransferase. It is closely related to the pyruvate dehydrogenase E2 component, dihydrolipoamide acetyltransferase. The seed for this model includes mitochondrial and Gram-negative bacterial forms. Mycobacterial candidates are highly derived, differ in having and extra copy of the lipoyl-binding domain at the N-terminus. They score below the trusted cutoff, but above the noise cutoff and above all examples of dihydrolipoamide acetyltransferase.
ReferencesDR PF00198; 2-oxoacid_dh DR PF00364; biotin_lipoyl
Genome PropertyGenProp0630: 2-oxoglutarate dehydrogenase system (HMM)