HMM Summary Page: TIGR01344

Functionmalate synthase A
Gene SymbolaceB
Trusted Cutoff594.50
Domain Trusted Cutoff594.50
Noise Cutoff122.10
Domain Noise Cutoff122.10
Isology Typeequivalog
EC Number2.3.3.9
HMM Length511
Mainrole CategoryEnergy metabolism
Subrole CategoryTCA cycle
Gene Ontology TermGO:0004474: malate synthase activity molecular_function
GO:0006099: tricarboxylic acid cycle biological_process
AuthorHaft DH
Entry DateSep 19 2001 3:52PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM represents plant malate synthase and one of two bacterial forms, designated malate synthase A. The distantly related malate synthase G is described by a separate model. This enzyme and isocitrate lyase are the two characteristic enzymes of the glyoxylate shunt. The shunt enables the cell to use acetyl-CoA to generate increased levels of TCA cycle intermediates for biosynthetic pathways such as gluconeogenesis.
ReferencesDR PFAM; PF01274; Malate synthase
Genome PropertyGenProp0023: glyoxylate shunt (HMM)