HMM Summary Page: TIGR01341

Functionaconitate hydratase 1
Gene SymbolacnA
Trusted Cutoff945.00
Domain Trusted Cutoff945.00
Noise Cutoff508.80
Domain Noise Cutoff508.80
Isology Typeequivalog
EC Number4.2.1.3
HMM Length876
Mainrole CategoryEnergy metabolism
Subrole CategoryTCA cycle
Gene Ontology TermGO:0003994: aconitate hydratase activity molecular_function
GO:0006099: tricarboxylic acid cycle biological_process
AuthorHaft DH
Entry DateSep 14 2001 11:38AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM represents one form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It is found in bacteria, archaea, and eukaryotic cytosol. It has been shown to act also as an iron-responsive element binding protein in animals and may have the same role in other eukaryotes.
ReferencesDR EXPERIMENTAL; SP:P70920; Bradyrhizobium japonicum DR EXPERIMENTAL; SP:P37032; Legionella pneumophila DR EXPERIMENTAL; SP|Q42560; Arabidopsis thaliana DR EXPERIMENTAL; GP|6456849; Streptomyces viridochromogenes RM 10748225 RT The aconitase function of iron regulatory protein 1. Genetic studies in yeast implicate its role in iron-mediated redox regulation. RA Narahari J, Ma R, Wang M, Walden WE. RL J Biol Chem 2000 May 26;275(21):16227-16234
Genome PropertyGenProp0033: TCA cycle (HMM)