| Accession | TIGR01341 |
| Name | aconitase_1 |
| Function | aconitate hydratase 1 |
| Gene Symbol | acnA |
| Trusted Cutoff | 945.00 |
| Domain Trusted Cutoff | 945.00 |
| Noise Cutoff | 508.80 |
| Domain Noise Cutoff | 508.80 |
| Isology Type | equivalog |
| EC Number | 4.2.1.3 |
| HMM Length | 876 |
| Mainrole Category | Energy metabolism |
| Subrole Category | TCA cycle |
| Gene Ontology Term | GO:0003994: aconitate hydratase activity molecular_function |
| | GO:0006099: tricarboxylic acid cycle biological_process |
| Author | Haft DH |
| Entry Date | Sep 14 2001 11:38AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This HMM represents one form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It is found in bacteria, archaea, and eukaryotic cytosol. It has been shown to act also as an iron-responsive element binding protein in animals and may have the same role in other eukaryotes. |
| References | DR EXPERIMENTAL; SP:P70920; Bradyrhizobium japonicum
DR EXPERIMENTAL; SP:P37032; Legionella pneumophila
DR EXPERIMENTAL; SP|Q42560; Arabidopsis thaliana
DR EXPERIMENTAL; GP|6456849; Streptomyces viridochromogenes
RM 10748225
RT The aconitase function of iron regulatory protein 1. Genetic studies in yeast implicate its role in iron-mediated redox regulation.
RA Narahari J, Ma R, Wang M, Walden WE.
RL J Biol Chem 2000 May 26;275(21):16227-16234 |
| Genome Property | GenProp0033: TCA cycle (HMM) |
