HMM Summary Page: TIGR01328

Functionmethionine gamma-lyase
Gene SymbolmegL
Trusted Cutoff549.70
Domain Trusted Cutoff549.70
Noise Cutoff466.75
Domain Noise Cutoff466.75
Isology Typeequivalog
EC Number4.4.1.11
HMM Length391
Mainrole CategoryEnergy metabolism
Subrole CategoryAmino acids and amines
Gene Ontology TermGO:0009087: methionine catabolic process biological_process
GO:0009093: cysteine catabolic process biological_process
GO:0018826: methionine gamma-lyase activity molecular_function
AuthorHaft DH
Entry DateAug 24 2001 2:12PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes a methionine gamma-lyase subset of a family of PLP-dependent trans-sulfuration enzymes. The member from the parasite Trichomonas vaginalis is described as catalyzing alpha gamma- and alpha-beta eliminations and gamma-replacement reactions on methionine, cysteine, and some derivatives. Likewise, the enzyme from Pseudomonas degrades cysteine as well as methionine.
ReferencesRM 1953661 RT Purification and characterization of methionine gamma-lyase from Trichomonas vaginalis. RA Lockwood BC, Coombs GH RL Biochem J 1991 Nov 1;279 ( Pt 3):675-82 DR PROSITE; PDOC00677; Cys/Met metabolism enzymes pyridoxal-phosphate attachment site DR EXPERIMENTAL; PIR:JC4174