HMM Summary Page: TIGR01320

Functionmalate dehydrogenase (acceptor)
Gene Symbolmqo
Trusted Cutoff549.95
Domain Trusted Cutoff549.95
Noise Cutoff197.40
Domain Noise Cutoff197.40
Isology Typeequivalog
EC Number1.1.5.4
HMM Length482
Mainrole CategoryEnergy metabolism
Subrole CategoryTCA cycle
Gene Ontology TermGO:0006099: tricarboxylic acid cycle biological_process
GO:0008924: malate dehydrogenase (quinone) activity molecular_function
AuthorHaft DH
Entry DateAug 6 2001 2:02PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis membrane-associated enzyme is an alternative to the better-known NAD-dependent malate dehydrogenase as part of the TCA cycle. The reduction of a quinone rather than NAD+ makes the reaction essentially irreversible in the direction of malate oxidation to oxaloacetate. Both forms of malate dehydrogenase are active in E. coli; disruption of this form causes less phenotypic change. In some bacteria, this form is the only or the more important malate dehydrogenase.
ReferencesRM 11092847 RT Functions of the membrane-associated and cytoplasmic malate dehydrogenases in the citric acid cycle of Escherichia coli. RA van der Rest ME, Frank C, Molenaar D. RL J Bacteriol 2000 Dec;182(24):6892-9RM 11092847 DR HAMAP; MF_00212; 117 of 129
Genome PropertyGenProp0033: TCA cycle (HMM)