| Accession | TIGR01320 |
| Name | mal_quin_oxido |
| Function | malate dehydrogenase (acceptor) |
| Gene Symbol | mqo |
| Trusted Cutoff | 549.95 |
| Domain Trusted Cutoff | 549.95 |
| Noise Cutoff | 197.40 |
| Domain Noise Cutoff | 197.40 |
| Isology Type | equivalog |
| EC Number | 1.1.5.4 |
| HMM Length | 482 |
| Mainrole Category | Energy metabolism |
| Subrole Category | TCA cycle |
| Gene Ontology Term | GO:0006099: tricarboxylic acid cycle biological_process |
| | GO:0008924: malate dehydrogenase (quinone) activity molecular_function |
| Author | Haft DH |
| Entry Date | Aug 6 2001 2:02PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This membrane-associated enzyme is an alternative to the better-known NAD-dependent malate dehydrogenase as part of the TCA cycle. The reduction of a quinone rather than NAD+ makes the reaction essentially irreversible in the direction of malate oxidation to oxaloacetate. Both forms of malate dehydrogenase are active in E. coli; disruption of this form causes less phenotypic change. In some bacteria, this form is the only or the more important malate dehydrogenase. |
| References | RM 11092847
RT Functions of the membrane-associated and cytoplasmic malate dehydrogenases in the citric acid cycle of Escherichia coli.
RA van der Rest ME, Frank C, Molenaar D.
RL J Bacteriol 2000 Dec;182(24):6892-9RM 11092847
DR HAMAP; MF_00212; 117 of 129 |
| Genome Property | GenProp0033: TCA cycle (HMM) |
