HMM Summary Page: TIGR01299

Functionsynaptic vesicle protein SV2
Trusted Cutoff637.30
Domain Trusted Cutoff637.30
Noise Cutoff236.15
Domain Noise Cutoff236.15
Isology Typesubfamily
HMM Length742
AuthorHaft DH, Paulsen IT
Entry DateJul 2 2001 2:27PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by PFAM HMM PF00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
ReferencesDR PF00083; sugar_tr; Sugar (and other) transporter RN [1] RM 10624962 RT SV2A and SV2B function as redundant Ca2+ regulators in neurotransmitter release. RA Janz R, Goda Y, Geppert M, Missler M, Sudhof TC RL Neuron 1999 Dec;24(4):1003-16 RN [2] RM 1355409 RT The synaptic vesicle protein SV2 is a novel type of transmembrane transporter. RA Feany MB, Lee S, Edwards RH, Buckley KM RL Cell 1992 Sep 4;70(5):861-7 DR URL;