Accession | TIGR01298 |
Name | RNaseT |
Function | ribonuclease T |
Gene Symbol | rnt |
Trusted Cutoff | 246.20 |
Domain Trusted Cutoff | 246.20 |
Noise Cutoff | 60.20 |
Domain Noise Cutoff | 60.20 |
Isology Type | equivalog |
EC Number | 3.1.13.- |
HMM Length | 200 |
Mainrole Category | Transcription |
Subrole Category | RNA processing |
Gene Ontology Term | GO:0006364: rRNA processing biological_process |
| GO:0016896: exoribonuclease activity, producing 5'-phosphomonoesters molecular_function |
| GO:0042780: tRNA 3'-end processing biological_process |
Author | Haft DH |
Entry Date | Jul 2 2001 12:22PM |
Last Modified | Feb 14 2011 3:27PM |
Comment | This HMM describes ribonuclease T, an enzyme found so far only
in gamma-subdivision Proteobacteria such as Escherichia coli and Xylella fastidiosa. Ribonuclease T is homologous to the DNA polymerase III alpha chain. It can liberate AMP from the common C-C-A terminus of uncharged tRNA. It appears also to be involved in RNA maturation. It also acts as a 3' to 5' single-strand DNA-specific exonuclease; it is distinctive for its ability to remove residues near a double-stranded stem. Ribonuclease T is a high copy suppressor in E. coli of a uv-repair defect caused by deletion of three other single-stranded DNA exonucleases. |
References | RN [1]
RM 9857048
RT Identification of a potent DNase activity associated with RNase T of Escherichia coli.
RA Viswanathan M, Dower KW, Lovett ST.
RL J Biol Chem 1998 Dec 25;273(52):35126-31
DR HAMAP; MF_00157; 80 of 81 |