HMM Summary Page: TIGR01273

Functionarginine decarboxylase
Gene SymbolspeA
Trusted Cutoff624.10
Domain Trusted Cutoff624.10
Noise Cutoff310.90
Domain Noise Cutoff310.90
Isology Typeequivalog
EC Number4.1.1.19
HMM Length624
Mainrole CategoryCentral intermediary metabolism
Subrole CategoryPolyamine biosynthesis
Gene Ontology TermGO:0008295: spermidine biosynthetic process biological_process
GO:0008792: arginine decarboxylase activity molecular_function
AuthorHaft DH
Entry DateJun 7 2001 9:26AM
Last ModifiedFeb 14 2011 3:27PM
CommentTwo alternative pathways can convert arginine to putrescine. One is decarboxylation by this enzyme followed by removal of the urea moeity by agmatinase. In the other, the ureohydrolase (arginase) acts first, followed by ornithine decarboxylase. This pathway leads to spermidine biosynthesis, hence the gene symbol speA. A distinct biodegradative form is also pyridoxal phosphate-dependent but is not similar in sequence.
ReferencesDR PFAM; PF00278; Pyridoxal-dependent decarboxylase DR HAMAP; MF_01417; 71 of 72
Genome PropertyGenProp0642: putrescine biosynthesis from arginine utilizing agmatinase (HMM)