| Accession | TIGR01273 |
| Name | speA |
| Function | arginine decarboxylase |
| Gene Symbol | speA |
| Trusted Cutoff | 624.10 |
| Domain Trusted Cutoff | 624.10 |
| Noise Cutoff | 310.90 |
| Domain Noise Cutoff | 310.90 |
| Isology Type | equivalog |
| EC Number | 4.1.1.19 |
| HMM Length | 624 |
| Mainrole Category | Central intermediary metabolism |
| Subrole Category | Polyamine biosynthesis |
| Gene Ontology Term | GO:0008295: spermidine biosynthetic process biological_process |
| | GO:0008792: arginine decarboxylase activity molecular_function |
| Author | Haft DH |
| Entry Date | Jun 7 2001 9:26AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Two alternative pathways can convert arginine to putrescine. One is decarboxylation by this enzyme followed by removal of the urea moeity by agmatinase. In the other, the ureohydrolase (arginase) acts first, followed by ornithine decarboxylase. This pathway leads to spermidine biosynthesis, hence the gene symbol speA.
A distinct biodegradative form is also pyridoxal phosphate-dependent but is not similar in sequence. |
| References | DR PFAM; PF00278; Pyridoxal-dependent decarboxylase
DR HAMAP; MF_01417; 71 of 72 |
| Genome Property | GenProp0642: putrescine biosynthesis from arginine utilizing agmatinase (HMM) |
