HMM Summary Page: TIGR01271

Functioncystic fibrosis transmembrane conductor regulator (CFTR)
Trusted Cutoff1761.20
Domain Trusted Cutoff1761.20
Noise Cutoff1208.30
Domain Noise Cutoff1208.30
Isology Typeequivalog
EC Number3.6.3.49
HMM Length1490
Mainrole CategoryTransport and binding proteins
Subrole CategoryAnions
Gene Ontology TermGO:0005260: channel-conductance-controlling ATPase activity molecular_function
GO:0030321: transepithelial chloride transport biological_process
AuthorLoftus BJ, Ujwal ML, Paulsen IT
Entry DateJun 6 2001 11:20AM
Last ModifiedFeb 14 2011 3:27PM
CommentThe model describes the cystis fibrosis transmembrane conductor regulator (CFTR) in eukaryotes. The principal role of this protein is chloride ion conductance. The protein is predicted to consist of 12 transmembrane domains. Mutations or lesions in the genetic loci have been linked to the aetiology of asthma, bronchiectasis, chronic obstructive pulmonary disease etc. Disease-causing mutations have been studied by 36Cl efflux assays in vitro cell cultures and electrophysiology, all of which point to the impairment of chloride channel stability and not the biosynthetic processing per se.