| Accession | TIGR01268 |
| Name | Phe4hydrox_tetr |
| Function | phenylalanine-4-hydroxylase |
| Trusted Cutoff | 704.80 |
| Domain Trusted Cutoff | 704.80 |
| Noise Cutoff | 674.95 |
| Domain Noise Cutoff | 674.95 |
| Isology Type | equivalog |
| EC Number | 1.14.16.1 |
| HMM Length | 436 |
| Gene Ontology Term | GO:0004505: phenylalanine 4-monooxygenase activity molecular_function |
| | GO:0006559: L-phenylalanine catabolic process biological_process |
| Author | Haft DH |
| Entry Date | Jun 5 2001 11:36AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This HMM describes the larger, tetrameric form of phenylalanine-4-hydroxylase, as found in metazoans. The enzyme irreversibly converts phenylalanine to tryosine and is known to be the rate-limiting step in phenylalanine catabolism in some systems. It is closely related to metazoan tyrosine 3-monooxygenase and tryptophan 5-monoxygenase, and more distantly to monomeric phenylalanine-4-hydroxylases of some Gram-negative bacteria.
The member of this family from Drosophila has been described as having both phenylalanine-4-hydroxylase and tryptophan 5-monoxygenase activity (PMID:1371286). However, a Drosophila member of the tryptophan 5-monoxygenase clade has subsequently been discovered. |
| References | DR EXPERIMENTAL; GP|4150981; Geodia cydonium (sponge)
DR EXPERIMENTAL; SP:P00439; Homo sapiens
DR OUTGROUP; SP:P17290; tryptophan 5-monoxygenase; rabbit
DR OUTGROUP; SP:P24529; tyrosine 3-monooxygenase; mouse |
