HMM Summary Page: TIGR01268

Trusted Cutoff704.80
Domain Trusted Cutoff704.80
Noise Cutoff674.95
Domain Noise Cutoff674.95
Isology Typeequivalog
EC Number1.14.16.1
HMM Length436
Gene Ontology TermGO:0004505: phenylalanine 4-monooxygenase activity molecular_function
GO:0006559: L-phenylalanine catabolic process biological_process
AuthorHaft DH
Entry DateJun 5 2001 11:36AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes the larger, tetrameric form of phenylalanine-4-hydroxylase, as found in metazoans. The enzyme irreversibly converts phenylalanine to tryosine and is known to be the rate-limiting step in phenylalanine catabolism in some systems. It is closely related to metazoan tyrosine 3-monooxygenase and tryptophan 5-monoxygenase, and more distantly to monomeric phenylalanine-4-hydroxylases of some Gram-negative bacteria. The member of this family from Drosophila has been described as having both phenylalanine-4-hydroxylase and tryptophan 5-monoxygenase activity (PMID:1371286). However, a Drosophila member of the tryptophan 5-monoxygenase clade has subsequently been discovered.
ReferencesDR EXPERIMENTAL; GP|4150981; Geodia cydonium (sponge) DR EXPERIMENTAL; SP:P00439; Homo sapiens DR OUTGROUP; SP:P17290; tryptophan 5-monoxygenase; rabbit DR OUTGROUP; SP:P24529; tyrosine 3-monooxygenase; mouse