| Accession | TIGR01267 |
| Name | Phe4hydrox_mono |
| Function | phenylalanine-4-hydroxylase |
| Gene Symbol | phhA |
| Trusted Cutoff | 264.75 |
| Domain Trusted Cutoff | 264.75 |
| Noise Cutoff | 182.45 |
| Domain Noise Cutoff | 182.45 |
| Isology Type | equivalog |
| EC Number | 1.14.16.1 |
| HMM Length | 248 |
| Mainrole Category | Energy metabolism |
| Subrole Category | Amino acids and amines |
| Gene Ontology Term | GO:0004505: phenylalanine 4-monooxygenase activity molecular_function |
| | GO:0006559: L-phenylalanine catabolic process biological_process |
| Author | Haft DH |
| Entry Date | Jun 5 2001 11:14AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This HMM describes the smaller, monomeric form of phenylalanine-4-hydroxylase, as found in a small number of Gram-negative bacteria. The enzyme irreversibly converts phenylalanine to tryosine and is known to be the rate-limiting step in phenylalanine catabolism in some systems.
This family is of biopterin and metal-dependent hydroxylases is related to a family of longer, multimeric aromatic amino acid hydroxylases that have additional N-terminal regulatory sequences. These include tyrosine 3-monooxygenase, phenylalanine-4-hydroxylase, and tryptophan 5-monoxygenase. |
| References | DR EXPERIMENTAL; SP|P30967; Chromobacterium violaceum
DR EXPERIMENTAL; SP:P43334; Pseudomonas aeruginosa |
| Genome Property | GenProp0045: tyrosine biosynthesis from chorismate (HMM) |
