Accession | TIGR01263 |
Name | 4HPPD |
Function | 4-hydroxyphenylpyruvate dioxygenase |
Gene Symbol | hppD |
Trusted Cutoff | 277.00 |
Domain Trusted Cutoff | 277.00 |
Noise Cutoff | 93.60 |
Domain Noise Cutoff | 93.60 |
Isology Type | equivalog |
EC Number | 1.13.11.27 |
HMM Length | 353 |
Mainrole Category | Energy metabolism |
Subrole Category | Amino acids and amines |
Gene Ontology Term | GO:0003868: 4-hydroxyphenylpyruvate dioxygenase activity molecular_function |
| GO:0006559: L-phenylalanine catabolic process biological_process |
| GO:0006572: tyrosine catabolic process biological_process |
Author | Haft DH |
Entry Date | Jun 1 2001 11:08AM |
Last Modified | Feb 14 2011 3:27PM |
Comment | This protein oxidizes 4-hydroxyphenylpyruvate, a tyrosine and phenylalanine catabolite, to homogentisate. Homogentisate can undergo a further non-enzymatic oxidation and polymerization into brown pigments that protect some bacterial species from light. A similar process occurs spontaneously in blood and is hemolytic (see PMID:8000039). In some bacterial species, this enzyme has been studied as a hemolysin. |
References | DR EXPERIMENTAL; EGAD|22485; Streptomyces avermitilis |
Genome Property | GenProp0139: degradation of tyrosine via homogentisate (HMM) |