HMM Summary Page: TIGR01262

Functionmaleylacetoacetate isomerase
Gene SymbolmaiA
Trusted Cutoff171.05
Domain Trusted Cutoff171.05
Noise Cutoff104.00
Domain Noise Cutoff104.00
Isology Typeequivalog
EC Number5.2.1.2
HMM Length211
Mainrole CategoryEnergy metabolism
Subrole CategoryAmino acids and amines
Gene Ontology TermGO:0006559: L-phenylalanine catabolic process biological_process
GO:0006572: tyrosine catabolic process biological_process
GO:0016034: maleylacetoacetate isomerase activity molecular_function
AuthorHaft DH
Entry DateMay 31 2001 3:36PM
Last ModifiedFeb 14 2011 3:27PM
CommentMaleylacetoacetate isomerase is an enzyme of tyrosine and phenylalanine catabolism. It requires glutathione and belongs by homology to the zeta family of glutathione S-transferases. The enzyme (EC is described as active also on maleylpyruvate, and the example from a Ralstonia sp. catabolic plasmid is described as a maleylpyruvate isomerase involved in gentisate catabolism.
ReferencesRM 9417084 RT Characterization of a fungal maleylacetoacetate isomerase gene and identification of its human homologue. RA Fernandez-Canon JM, Penalva MA. RL J Biol Chem 1998 Jan 2;273(1):329-37 DR EXPERIMENTAL; SP|O43123; Aspergillus nidulans DR EXPERIMENTAL; SP|O43708; Homo sapiens
Genome PropertyGenProp0139: degradation of tyrosine via homogentisate (HMM)