| Accession | TIGR01262 |
| Name | maiA |
| Function | maleylacetoacetate isomerase |
| Gene Symbol | maiA |
| Trusted Cutoff | 171.05 |
| Domain Trusted Cutoff | 171.05 |
| Noise Cutoff | 104.00 |
| Domain Noise Cutoff | 104.00 |
| Isology Type | equivalog |
| EC Number | 5.2.1.2 |
| HMM Length | 211 |
| Mainrole Category | Energy metabolism |
| Subrole Category | Amino acids and amines |
| Gene Ontology Term | GO:0006559: L-phenylalanine catabolic process biological_process |
| | GO:0006572: tyrosine catabolic process biological_process |
| | GO:0016034: maleylacetoacetate isomerase activity molecular_function |
| Author | Haft DH |
| Entry Date | May 31 2001 3:36PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Maleylacetoacetate isomerase is an enzyme of tyrosine and phenylalanine catabolism. It requires glutathione and belongs by homology to the zeta family of glutathione S-transferases. The enzyme (EC 5.2.1.2) is described as active also on maleylpyruvate, and the example from a Ralstonia sp. catabolic plasmid is described as a maleylpyruvate isomerase involved in gentisate catabolism. |
| References | RM 9417084
RT Characterization of a fungal maleylacetoacetate isomerase gene and identification of its human homologue.
RA Fernandez-Canon JM, Penalva MA.
RL J Biol Chem 1998 Jan 2;273(1):329-37
DR EXPERIMENTAL; SP|O43123; Aspergillus nidulans
DR EXPERIMENTAL; SP|O43708; Homo sapiens |
| Genome Property | GenProp0139: degradation of tyrosine via homogentisate (HMM) |
