HMM Summary Page: TIGR01254

FunctionABC transporter periplasmic binding protein, thiB subfamily
Trusted Cutoff93.40
Domain Trusted Cutoff93.40
Noise Cutoff76.00
Domain Noise Cutoff76.00
Isology Typesubfamily
HMM Length306
Mainrole CategoryTransport and binding proteins
Subrole CategoryOther
Gene Ontology TermGO:0009897: external side of plasma membrane cellular_component
GO:0015619: thiamine pyrophosphate-transporting ATPase activity molecular_function
GO:0015888: thiamine transport biological_process
GO:0030288: outer membrane-bounded periplasmic space cellular_component
GO:0030974: thiamine pyrophosphate transport biological_process
GO:0030975: thiamine binding molecular_function
GO:0030976: thiamine pyrophosphate binding molecular_function
GO:0048502: thiamine-transporting ATPase activity molecular_function
GO:0055052: ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing cellular_component
AuthorUjwal ML, Paulsen IT
Entry DateMay 22 2001 4:09PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe model describes thiamine ABC transporter, periplasmic protein in bacteria and archae. The protein belongs to the larger ABC transport system. It consists of at least three components: the thiamine binding periplasmic protein; an inner membrane permease; an ATP-binding subunit. It has been experimentally demonstrated that the mutants in the various steps in the de novo synthesis of the thiamine and the biologically active form, namely thiamine pyrophosphate can be exogenously supplemented with thiamine, thiamine monophosphate (TMP) or thiamine pyrophosphate (TPP).