HMM Summary Page: TIGR01253

Functionthiamine/thiamine pyrophosphate ABC transporter, permease protein
Gene SymbolthiP
Trusted Cutoff395.10
Domain Trusted Cutoff395.10
Noise Cutoff234.10
Domain Noise Cutoff234.10
Isology Typeequivalog
HMM Length519
Mainrole CategoryTransport and binding proteins
Subrole CategoryOther
Gene Ontology TermGO:0005887: integral to plasma membrane cellular_component
GO:0015619: thiamine pyrophosphate-transporting ATPase activity molecular_function
GO:0015888: thiamine transport biological_process
GO:0030974: thiamine pyrophosphate transport biological_process
GO:0048502: thiamine-transporting ATPase activity molecular_function
GO:0055052: ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing cellular_component
AuthorUjwal ML, Haft DH, Paulsen IT
Entry DateMay 22 2001 3:45PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe model describes thiamine ABC transporter, permease protein in bacteria. The protein belongs to the larger ABC transport system. It consists of atleast three components: the inner mebrane permease; thiamine binding protein; an ATP-binding subunit. It has been experimentally demonstrated that the mutants in the various steps in the de novo synthesis of the thiamine and the biologically active form, namely thiamine pyrophosphate can be exogenously supplemented with thiamine, thiamine monophosphate (TMP) or thiamine pyrophosphate (TPP).
ReferencesRM 98204886 RT thiBPQ encodes an ABC transporter required for transport of thiamine and thiamine pyrophosphate in Salmonella typhimurium. RA Webb E, Claas K, Downs D. RL J Biol Chem 1998 Apr 10;273(15):8946-50
Genome PropertyGenProp0252: thiamine/TPP ABC transporter ThiBPQ (HMM)