HMM Summary Page: TIGR01251

Functionribose-phosphate diphosphokinase
Gene Symbolprs
Trusted Cutoff113.00
Domain Trusted Cutoff113.00
Noise Cutoff107.35
Domain Noise Cutoff107.35
Isology Typesubfamily
EC Number2.7.6.1
HMM Length309
Mainrole CategoryPurines, pyrimidines, nucleosides, and nucleotides
Subrole CategoryPurine ribonucleotide biosynthesis
Gene Ontology TermGO:0004749: ribose phosphate diphosphokinase activity molecular_function
GO:0009152: purine ribonucleotide biosynthetic process biological_process
AuthorHaft DH
Entry DateMay 17 2001 4:16PM
Last ModifiedFeb 14 2011 3:27PM
CommentAlternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason.
ReferencesRN [1] RM 8132556 RT A novel 39-kDa phosphoribosylpyrophosphate synthetase-associated protein of rat liver. Cloning, high sequence similarity to the catalytic subunits, and a negative regulatory role. RA Kita K, Ishizuka T, Ishijima S, Sonoda T, Tatibana M. RL J Biol Chem 1994 Mar 18;269(11):8334-40 DR HAMAP; MF_00583; 155 of 155
Genome PropertyGenProp0109: histidine biosynthesis from ribose-5-phosphate (HMM)
GenProp0110: purine (inosine-5'-phosphate) biosynthesis from ribose-5-phosphate (HMM)
GenProp0037: tryptophan biosynthesis from ribose-5-phosphate (HMM)
GenProp0187: pyrimidine (uridine-5'-phosphate) de novo biosynthesis (HMM)
GenProp0800: bacterial core gene set, 1 or more per genome (HMM)