HMM Summary Page: TIGR01248

Functiondaunorubicin resistance protein C
Trusted Cutoff165.65
Domain Trusted Cutoff165.65
Noise Cutoff74.80
Domain Noise Cutoff74.80
Isology Typesubfamily
HMM Length152
Mainrole CategoryUnclassified
Subrole CategoryRole category not yet assigned
AuthorUjwal ML, Paulsen IT
Entry DateMay 16 2001 7:35PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe model describes daunorubicin resistance protein C in bacteria. This protein confers the function of daunorubicin resistance. The protein seems to share strong sequence similarity to UvrA proteins, which are involved in excision repair of DNA. Disruption of drrC gene showed increased sensitivity upon exposure to duanorubicin. However it failed to complement uvrA mutants to exposure to UV irradiation. The mechanism on how it confers duanomycin resistance is unclear, but has been suggested to be different from DrrA and DrrB which are antiporters.