HMM Summary Page: TIGR01247

Functiondaunorubicin resistance ABC transporter membrane protein
Trusted Cutoff223.05
Domain Trusted Cutoff223.05
Noise Cutoff126.20
Domain Noise Cutoff126.20
Isology Typesubfamily
HMM Length236
Mainrole CategoryTransport and binding proteins
Subrole CategoryOther
Gene Ontology TermGO:0005887: integral to plasma membrane cellular_component
GO:0043190: ATP-binding cassette (ABC) transporter complex cellular_component
GO:0043215: daunorubicin transport biological_process
GO:0043216: daunorubicin-transporting ATPase activity molecular_function
AuthorUjwal ML, Paulsen IT
Entry DateMay 16 2001 5:16PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model describes daunorubicin resistance ABC transporter, membrane associated protein in bacteria and archaea. The protein associated with effux of the drug, daunorubicin. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these transporter is the obligatory coupling of ATP hydrolysis to substrate translocation. The minimal configuration of bacterial ABC transport system: an ATPase or ATP binding subunit; An integral membrane protein; a hydrophilic polypetpide, which likely functions as substrate binding protein. In eukaryotes proteins of similar function include p-gyco proteins, multidrug resistance protein etc.