HMM Summary Page: TIGR01246

Functionsuccinyl-diaminopimelate desuccinylase
Gene SymboldapE
Trusted Cutoff361.80
Domain Trusted Cutoff361.80
Noise Cutoff192.30
Domain Noise Cutoff192.30
Isology Typeequivalog
EC Number3.5.1.18
HMM Length370
Mainrole CategoryAmino acid biosynthesis
Subrole CategoryAspartate family
Gene Ontology TermGO:0009014: succinyl-diaminopimelate desuccinylase activity molecular_function
GO:0009089: lysine biosynthetic process via diaminopimelate biological_process
AuthorHaft DH
Entry DateMay 16 2001 11:09AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes a proteobacterial subset of succinyl-diaminopimelate desuccinylases. An experimentally confirmed Gram-positive lineage succinyl-diaminopimelate desuccinylase has been described for Corynebacterium glutamicum (SP:Q59284), and a neighbor-joining tree shows the seed members, SP:Q59284, and putative archaeal members such as TrEMBL:O58003 in a single clade. However, the archaeal members differ substantially, share a number of motifs with acetylornithine deacetylases rather than succinyl-diaminopimelate desuccinylases, and are not taken as trusted examples of succinyl-diaminopimelate desuccinylases. This model is limited to proteobacterial members for this reason.
Genome PropertyGenProp0786: lysine biosynthesis via diaminopimelate (DAP), succinylated branch (HMM)