HMM Summary Page: TIGR01230

Gene SymbolspeB
Trusted Cutoff174.30
Domain Trusted Cutoff174.30
Noise Cutoff141.00
Domain Noise Cutoff141.00
Isology Typeequivalog
EC Number3.5.3.11
HMM Length275
Gene Ontology TermGO:0008295: spermidine biosynthetic process biological_process
GO:0008783: agmatinase activity molecular_function
AuthorHaft DH
Entry DateMay 8 2001 11:06AM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family include known and predicted examples of agmatinase (agmatine ureohydrolase). The seed includes members of archaea, for which no definitive agmatinase sequence has yet been made available. However, archaeal sequences are phylogenetically close to the experimentally verified B. subtilis sequence. One species of Halobacterium has been demonstrated in vitro to produce agmatine from arginine, but no putrescine from ornithine, suggesting that arginine decarboxylase and agmatinase, rather than arginase and ornithine decarboxylase, lead from Arg to polyamine biosynthesis. Note: a history of early misannotation of members of this family is detailed in PUBMED:10931887.
ReferencesDR EXPERIMENTAL; EGAD|47504; Synechocystis PCC6803 DR EXPERIMENTAL; GP|10184435; Neisseria gonorrhoeae RM 10931887 RT Phylogeny of related functions: the case of polyamine biosynthetic enzymes. RA Sekowska A, Danchin A, Risler JL RL Microbiology 2000 Aug;146 ( Pt 8):1815-28 DR HAMAP; MF_01418; 33 of 34
Genome PropertyGenProp0642: putrescine biosynthesis from arginine utilizing agmatinase (HMM)