HMM Summary Page: TIGR01226

Functionphenylalanine ammonia-lyase
Trusted Cutoff519.15
Domain Trusted Cutoff519.15
Noise Cutoff301.90
Domain Noise Cutoff301.90
Isology Typeequivalog
EC Number4.3.1.24
HMM Length680
Gene Ontology TermGO:0009698: phenylpropanoid metabolic process biological_process
GO:0016841: ammonia-lyase activity molecular_function
AuthorHaft DH
Entry DateMay 4 2001 1:48PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this subfamily of MIO prosthetic group enzymes are phenylalanine ammonia-lyases. They are found, so far, in plants and fungi. From phenylalanine, this enzyme yields cinnaminic acid, a precursor of many important plant compounds. This protein shows extensive homology to histidine ammonia-lyase, the first enzyme of a histidine degradation pathway. Note that members of this family from plant species that synthesize taxol are actually phenylalanine aminomutase, and are covered by exception model TIGR04473.
ReferencesRN [1] RM PMID:20577998 RT Probing the active site of MIO-dependent aminomutases, key catalysts in the biosynthesis of beta-amino acids incorporated in secondary metabolites. RA Cooke HA, Bruner SD RL Biopolymers. 2010 Sep;93(9):802-10. doi: 10.1002/bip.21500.