HMM Summary Page: TIGR01219

Functionphosphomevalonate kinase
Trusted Cutoff376.95
Domain Trusted Cutoff376.95
Noise Cutoff102.80
Domain Noise Cutoff102.80
Isology Typeequivalog
EC Number2.7.4.2
HMM Length456
Mainrole CategoryCentral intermediary metabolism
Subrole CategoryOther
Gene Ontology TermGO:0004631: phosphomevalonate kinase activity molecular_function
GO:0016126: sterol biosynthetic process biological_process
GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway biological_process
AuthorHaft DH
Entry DateMay 3 2001 10:44AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis enzyme is part of the mevalonate pathway, one of two alternative pathways for the biosynthesis of IPP. In an example of nonorthologous gene displacement, two different types of phosphomevalonate kinase are found - the animal type and this ERG8 type. This model represents plant and fungal forms of the ERG8 type of phosphomevalonate kinase.
ReferencesRM 11243736 RT Nonorthologous gene displacement of phosphomevalonate kinase. RA Houten SM, Waterham HR. RL Mol Genet Metab 2001 Mar;72(3):273-6
Genome PropertyGenProp0047: IPP biosynthesis via mevalonate (HMM)