HMM Summary Page: TIGR01212

Functionradical SAM protein, TIGR01212 family
Trusted Cutoff180.00
Domain Trusted Cutoff180.00
Noise Cutoff120.00
Domain Noise Cutoff120.00
Isology Typehypoth_equivalog
HMM Length302
Mainrole CategoryUnknown function
Subrole CategoryEnzymes of unknown specificity
AuthorHaft DH
Entry DateApr 3 2001 11:50AM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family are apparent radical-SAM enzymes, related to the N-terminal region of the bifunctional ELP3, whose C-terminal region is part of the elongator complex and appears to acetylate histones and other proteins. ELP3 binds S-adenosylmethionine (SAM) and was recently shown to be involved in a DNA demethylation process in eukaryotes. Close sequence similarity of this family (with lacks the GNAT family acetyltransferase domain) to the ELP3 N-terminal region and a strong match to the Pfam model PF04055 support identification of this family as radical SAM despite the atypical spacing between first and second Cys residues in the 4Fe4S-binding motif.
ReferencesRN [1] RM PMID:20054296 RT A role for the elongator complex in zygotic paternal genome demethylation. RA Okada Y, Yamagata K, Hong K, Wakayama T, Zhang Y RL Nature. 2010 Jan 28;463(7280):554-8. doi: 10.1038/nature08732. DR PFAM; PF04055