HMM Summary Page: TIGR01211

Functionradical SAM enzyme/protein acetyltransferase, ELP3 family
Trusted Cutoff350.00
Domain Trusted Cutoff350.00
Noise Cutoff160.00
Domain Noise Cutoff160.00
Isology Typesubfamily
EC Number2.3.1.48
HMM Length522
Mainrole CategoryTranscription
Subrole CategoryDNA-dependent RNA polymerase
AuthorHaft DH
Entry DateApr 3 2001 10:27AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis family includes elongator complex protein 3 (ELP3) from eukaryotes and related proteins from other lineages. ELP3 is a component of the RNA polymerase II holoenzyme. It has an N-terminal radical SAM domain and C-terminal GNAT acetyltransferase domain. Members of this family are found in eukaryotes, archaea, and a few bacteria (e.g. Atopobium sp). The activity discovered first was an acetyltransferase modification at the N-termini of all four core histones, shown in vitro in eukaryotes. More recently, the radical SAM domain was shown to play a role in zygotic paternal genome demethylation. Family TIGR01212, widespread in prokaryotes, lacks the GNAT acetyltransferase domain but shares extensive sequence similarity with this family (TIGR01211).
ReferencesDR COGS; COG1243 RN [1] RM PMID:10445034 RT A novel histone acetyltransferase is an integral subunit of elongating RNA polymerase II holoenzyme. RA Wittschieben BO, Otero G, de Bizemont T, Fellows J, Erdjument-Bromage H, Ohba R, Li Y, Allis CD, Tempst P, Svejstrup JQ RL Mol Cell. 1999 Jul;4(1):123-8. RN [2] RM PMID:20054296 RT A role for the elongator complex in zygotic paternal genome demethylation. RA Okada Y, Yamagata K, Hong K, Wakayama T, Zhang Y RL Nature. 2010 Jan 28;463(7280):554-8. doi: 10.1038/nature08732.