HMM Summary Page: TIGR01209

FunctionRNA ligase, Pab1020 family
Trusted Cutoff136.90
Domain Trusted Cutoff136.90
Noise Cutoff136.60
Domain Noise Cutoff136.60
Isology Typehypoth_equivalog
HMM Length375
Mainrole CategoryTranscription
Subrole CategoryRNA processing
Gene Ontology TermGO:0005737: cytoplasm cellular_component
GO:0008452: RNA ligase activity molecular_function
GO:0016070: RNA metabolic process biological_process
AuthorHaft DH
Entry DateMar 26 2001 4:15PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family are found, so far, in a single copy per genome and largely in thermophiles, of which only Aquifex aeolicus is bacterial rather than archaeal. PSI-BLAST converges after a single iteration to the whole of this family and reveals no convincing similarity to any other protein. The member protein Pab1020 has been characterized as an RNA ligase with circularization activity.
ReferencesRN [1] RM PMID:18511537 RT The structure of an archaeal homodimeric ligase which has RNA circularization activity. RA Brooks MA, Meslet-Cladiere L, Graille M, Kuhn J, Blondeau K, Myllykallio H, van Tilbeurgh H RL Protein Sci. 2008 Aug;17(8):1336-45. Epub 2008 May 29. DR COGS; COG1423
Genome PropertyGenProp0898: RNA ligase/unknown protein pair (HMM)