HMM Summary Page: TIGR01208

Functionglucose-1-phosphate thymidylyltransferase
Trusted Cutoff320.25
Domain Trusted Cutoff320.25
Noise Cutoff196.85
Domain Noise Cutoff196.85
Isology Typeequivalog
EC Number2.7.7.24
HMM Length353
Gene Ontology TermGO:0000271: polysaccharide biosynthetic process biological_process
GO:0008879: glucose-1-phosphate thymidylyltransferase activity molecular_function
AuthorHaft DH
Entry DateMar 21 2001 3:24PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe family of known and putative glucose-1-phosphate thymidyltransferase (also called dTDP-glucose synthase) shows a deep split into a short form (see TIGR01207) and a long form described by this model. The homotetrameric short form is found in numerous bacterial species that incorporate dTDP-L-rhamnose, which it helps synthesize, into the cell wall. It is subject to feedback inhibition. This form, in contrast, is found in many species for which it serves as a sugar-activating enzyme for antibiotic biosynthesis and or other, unknown pathways, and in which dTDP-L-rhamnose is not necessarily produced. Alternate name: dTDP-D-glucose synthase
ReferencesDR COGS; COG1209
Genome PropertyGenProp0950: 4,6-dideoxy-4-oxo-dTDP-D-glucose biosynthesis from glucose-1-phosphate (HMM)