HMM Summary Page: TIGR01207

Functionglucose-1-phosphate thymidylyltransferase
Gene SymbolrfbA
Trusted Cutoff360.65
Domain Trusted Cutoff360.65
Noise Cutoff189.50
Domain Noise Cutoff189.50
Isology Typeequivalog
EC Number2.7.7.24
HMM Length286
Mainrole CategoryCell envelope
Subrole CategoryBiosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Gene Ontology TermGO:0008879: glucose-1-phosphate thymidylyltransferase activity molecular_function
GO:0009243: O antigen biosynthetic process biological_process
GO:0019305: dTDP-rhamnose biosynthetic process biological_process
AuthorHaft DH
Entry DateMar 21 2001 2:37PM
Last ModifiedFeb 14 2011 3:27PM
CommentAlternate name: dTDP-D-glucose synthase homotetramer This HMM describes a tightly conserved but broadly distributed subfamily (here designated as short form) of known and putative bacterial glucose-1-phosphate thymidylyltransferases. It is well characterized in several species as the first of four enzymes involved in the biosynthesis of dTDP-L-rhamnose, a cell wall constituent and a feedback inhibitor of the enzyme.
ReferencesDR EXPERIMENTAL; EGAD|17315; Salmonella enterica DR EXPERIMENTAL; OMNI|NT03PA5970; Pseudomonas aeruginosa DR COGS; COG1209
Genome PropertyGenProp0950: 4,6-dideoxy-4-oxo-dTDP-D-glucose biosynthesis from glucose-1-phosphate (HMM)
GenProp0912: Leptospira exopolysaccharide biosynthesis clusters (HMM-CLUST)