HMM Summary Page: TIGR01203

Functionhypoxanthine phosphoribosyltransferase
Gene Symbolhpt
Trusted Cutoff150.00
Domain Trusted Cutoff150.00
Noise Cutoff62.10
Domain Noise Cutoff62.10
Isology Typeequivalog
EC Number2.4.2.8
HMM Length167
Mainrole CategoryPurines, pyrimidines, nucleosides, and nucleotides
Subrole CategorySalvage of nucleosides and nucleotides
Gene Ontology TermGO:0004422: hypoxanthine phosphoribosyltransferase activity molecular_function
GO:0006166: purine ribonucleoside salvage biological_process
AuthorHaft DH
Entry DateMar 15 2001 8:52AM
Last ModifiedFeb 14 2011 3:27PM
CommentAlternate name: hypoxanthine-guanine phosphoribosyltransferase. Sequence differences as small as a single residue can affect whether members of this family act on hypoxanthine and guanine or hypoxanthine only. The designation of this model as equivalog reflects hypoxanthine specificity and does not reflect whether or not guanine can replace hypoxanthine.
ReferencesRM 9521670 RT A single amino acid substitution in the human and a bacterial hypoxanthine phosphoribosyltransferase modulates specificity for the binding of guanine. RA Lee CC, Craig SP, Eakin AE RL Biochemistry 1998 Mar 10;37(10):3491-8